Accelerate your drug discovery program with Protease Screening and Profiling Services from BPS Bioscience, Inc. Trust us to provide you with high quality data with fast turnaround time. Our team of experts along with our broad services portfolio makes it easy to:
Screen for inhibitors/targets using our panel of many different assays including Cathepsins, Caspases, Dipeptidyl Peptidases (DPPs), Deubiquitinases, and other Proteases
Select from IC50 determination and single point concentrations
Receive data within days of compound submission
Perform follow-up studies using the same proteins manufactured in-house
Get questions answered or project guidance in a time-efficient manner
Biochemical Assays:
| Aspartic Proteases | Cysteine Proteases | Metalloproteases | Serine Proteases |
|---|
| BACE1 | SARS-CoV-1 3C-like Protease (3CL) | ADAM17 | CLP |
| Caspase-3 | SARS-CoV-2 3C-like Protease (3CL) | MMP1 | DPP3 |
| Caspase-6 | SARS-CoV-2 Papain-like Protease (PLPro) | MMP2 | DPP4 |
| Caspase-7 | A20 | MMP3 | DPP7 |
| Caspase-8 | Ataxin-3 | MMP7 | DPP8 |
| Caspase-9 | Cathepsin B | MMP8 | DPP9 |
| Renin, activated | Cathepsin F | MMP9 (Q279R) | FAP |
| | Cathepsin L | MMP10 | Furin |
| | Cathepsin S | MMP11 | HCV1a (D168V) |
| | Cathepsin V | MMP12 | HCV1b |
| | MALT1 | MMP13 | HCV1b (D168V) |
| | OTUD6Bc | MMP14 | HCV1b (R155K) |
| | UCHL1 | | HCV1b (R155Q) |
| | UCHL3 | | HCV2a |
| | USP2 | | POP |
| | USP5 | | Protein C, activated |
| | USP7 | | TMPRSS2 |
| | USP8 | | |
| | USP10 | | |
| | USP14 | | |
Note: Not all targets will have a commercially available reference control. Please inquire with our team if you need to furnish your own controls for specific targets.
Protease signaling pathways regulate a wide range of vital physiological processes, including digestion of food, lysosome and proteasome degradation, apoptosis, blood coagulation, and cell cycle regulation.
The dysregulation of protease activity can lead to pathologies such as arthritis and inflammatory diseases,cardiovascular disorders, cancer, osteoporosis, Alzheimer’s, and other neurological disorders. Several small molecule, protease inhibitor drugs are already on the market and many more are in development.
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